AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway.

@article{Sanli2014AMPactivatedPK,
  title={AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway.},
  author={Toran Sanli and Gregory R Steinberg and Gurmit Singh and Theodoros K Tsakiridis},
  journal={Cancer biology & therapy},
  year={2014},
  volume={15 2},
  pages={156-69}
}
AMP-activated protein kinase (AMPK), an established metabolic stress sensor, has gained popularity in cancer biology due to its ability to control cellular growth and mediate cell cycle checkpoints in cancer cells in response to low energy levels. AMPK is a key effector of the tumor suppressor liver kinase B 1 (LKB1) which inhibits the cellular growth mediator mammalian target of rapamycin (mTOR) and activates checkpoint mediators such as p53 and the cyclin dependent kinase inhibitors p21(cip1… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 54 extracted citations

Lycorine Induces Apoptosis of A549 Cells via AMPK-Mammalian Target of Rapamycin (mTOR)-S6K Signaling Pathway

Medical science monitor : international medical journal of experimental and clinical research • 2017
View 4 Excerpts
Highly Influenced

Identification of ATIC as a Novel Target for Chemoradiosensitization.

International journal of radiation oncology, biology, physics • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…