AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.

@article{Hardie2014AMPactivatedPK,
  title={AMP-activated protein kinase: maintaining energy homeostasis at the cellular and whole-body levels.},
  author={David Grahame Hardie},
  journal={Annual review of nutrition},
  year={2014},
  volume={34},
  pages={
          31-55
        }
}
The adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway arose early during evolution of eukaryotic cells, when it appears to have been involved in the response to glucose starvation and perhaps also in monitoring the output of the newly acquired mitochondria. Due to the advent of hormonal regulation of glucose homeostasis, glucose starvation is a less frequent event for mammalian cells than for single-celled eukaryotes. Nevertheless, the AMPK system has been… CONTINUE READING
Highly Cited
This paper has 19 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 15 citations