AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

  title={AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.},
  author={Barbara B. Kahn and Thierry Alquier and David Carling and David Grahame Hardie},
  journal={Cell metabolism},
  volume={1 1},
The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of cellular energy status, and recent data demonstrate that it also plays a critical role in systemic energy balance. AMPK integrates nutritional and hormonal signals in peripheral tissues and the hypothalamus. It mediates effects of adipokines (leptin, adiponectin, and possibly resistin) in regulating food intake, body weight, and glucose and lipid homeostasis. AMPK is regulated by upstream kinases of which the tumor… CONTINUE READING
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