AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.

@article{Leclerc2004AMPactivatedPK,
  title={AMP-activated protein kinase: a new beta-cell glucose sensor?: Regulation by amino acids and calcium ions.},
  author={Isabelle Leclerc and Guy A Rutter},
  journal={Diabetes},
  year={2004},
  volume={53 Suppl 3},
  pages={S67-74}
}
Stimulation of AMP-activated protein kinase (AMPK) in skeletal muscle and liver is seen as an exciting prospect for the treatment of type 2 diabetes. However, we have recently demonstrated that changes in AMPK activity accompany the exposure of pancreatic islet beta-cells to elevated glucose concentrations and may be involved in the activation of insulin secretion. Here, we discuss this hypothesis and explore the potential role of changes in AMPK activity in the actions of other secretagogues… CONTINUE READING
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