AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

@article{Hardie2011AMPactivatedPK,
  title={AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.},
  author={David Grahame Hardie},
  journal={Biochemical Society transactions},
  year={2011},
  volume={39 1},
  pages={1-13}
}
It is essential to life that a balance is maintained between processes that produce ATP and those that consume it. An obvious way to do this would be to have systems that monitor the levels of ATP and ADP, although because of the adenylate kinase reaction (2ADP↔ATP+AMP), AMP is actually a more sensitive indicator of energy stress than ADP. Following the discoveries that glycogen phosphorylase and phosphofructokinase were regulated by AMP and ATP, Daniel Atkinson proposed that all enzymes at… CONTINUE READING
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The Ca 2 + / calmoldulin - dependent protein kinase kinases are AMP - activated protein kinase kinases

  • S. Fogarty, S. A. Hawley, K. A. Green, N. Saner, K. J. Mustard, D. G. Hardie
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  • 2010

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