AMP-activated kinase is a regulator of fibroblast growth factor 23 production.

  title={AMP-activated kinase is a regulator of fibroblast growth factor 23 production.},
  author={Philipp Glosse and Martina Feger and Kerim Mutig and Honglei Chen and Frank Hirche and Ahmed Abdallah Hasan and Mohamed M S Gaballa and Berthold Hocher and Florian Lang and Michael F{\"o}ller},
  journal={Kidney international},
  volume={94 3},
Fibroblast growth factor 23 (FGF23) is a proteohormone regulating renal phosphate transport and vitamin D metabolism as well as inducing left heart hypertrophy. FGF23-deficient mice suffer from severe tissue calcification, accelerated aging and a myriad of aging-associated diseases. Bone cells produce FGF23 upon store-operated calcium ion entry (SOCE) through the calcium selective ion channel Orai1. AMP-activated kinase (AMPK) is a powerful energy sensor helping cells survive states of energy… CONTINUE READING