AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5

@article{McGee2008AMPActivatedPK,
  title={AMP-Activated Protein Kinase Regulates GLUT4 Transcription by Phosphorylating Histone Deacetylase 5},
  author={Sean L. McGee and Bryce J. W. van Denderen and Kirsten F. Howlett and Janelle P. Mollica and Jonathan D. Schertzer and Bruce E. Kemp and Mark Hargreaves},
  journal={Diabetes},
  year={2008},
  volume={57},
  pages={860 - 867}
}
OBJECTIVE—Insulin resistance associated with obesity and diabetes is ameliorated by specific overexpression of GLUT4 in skeletal muscle. The molecular mechanisms regulating skeletal muscle GLUT4 expression remain to be elucidated. The purpose of this study was to examine these mechanisms. RESEARCH DESIGN AND METHODS AND RESULTS—Here, we report that AMP-activated protein kinase (AMPK) regulates GLUT4 transcription through the histone deacetylase (HDAC)5 transcriptional repressor. Overexpression… 

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