AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol

@inproceedings{Um2010AMPActivatedPK,
  title={AMP-Activated Protein Kinase–Deficient Mice Are Resistant to the Metabolic Effects of Resveratrol},
  author={Jee-Hyun Um and Sung-Jun Park and Hyeog Kang and Stanley Yang and Marc Foretz and Michael W McBurney and Myung Kyoo Kim and Benoit Viollet and Jay H. Chung},
  booktitle={Diabetes},
  year={2010}
}
OBJECTIVE Resveratrol, a natural polyphenolic compound that is found in grapes and red wine, increases metabolic rate, insulin sensitivity, mitochondrial biogenesis, and physical endurance and reduces fat accumulation in mice. Although it is thought that resveratrol targets Sirt1, this is controversial because resveratrol also activates 5' AMP-activated protein kinase (AMPK), which also regulates insulin sensitivity and mitochondrial biogenesis. Here, we use mice deficient in AMPKalpha1 or… CONTINUE READING
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