AMP‐activated protein kinase: the energy charge hypothesis revisited

  title={AMP‐activated protein kinase: the energy charge hypothesis revisited},
  author={D. Hardie and S. Hawley},
  • D. Hardie, S. Hawley
  • Published 2001
  • Biology, Medicine
  • BioEssays
  • The AMP‐activated protein kinase cascade is a sensor of cellular energy charge, and its existence provides strong support for the energy charge hypothesis first proposed by Daniel Atkinson in the 1960s. The system is activated in an ultrasensitive manner by cellular stresses that deplete ATP (and consequently elevate AMP), either by inhibiting ATP production (e.g., hypoxia), or by accelerating ATP consumption (e.g., exercise in muscle). Once activated, it switches on catabolic pathways, both… CONTINUE READING
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