AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin1

@article{Couderc2016AMOTL1PB,
  title={AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin1},
  author={C. Couderc and A. Boin and L. Fuhrmann and A. Vincent-Salomon and Vinay Mandati and Y. Kieffer and F. Mechta-Grigoriou and L. Del Maestro and P. Chavrier and D. Vallerand and I. Brito and T. Dubois and L. de Koning and D. Bouvard and D. Louvard and A. Gautreau and D. Lallemand},
  journal={Neoplasia (New York, N.Y.)},
  year={2016},
  volume={18},
  pages={10 - 24}
}
  • C. Couderc, A. Boin, +14 authors D. Lallemand
  • Published 2016
  • Biology, Medicine
  • Neoplasia (New York, N.Y.)
  • The Hippo signaling network is a key regulator of cell fate. In the recent years, it was shown that its implication in cancer goes well beyond the sole role of YAP transcriptional activity and its regulation by the canonical MST/LATS kinase cascade. Here we show that the motin family member AMOTL1 is an important effector of Hippo signaling in breast cancer. AMOTL1 connects Hippo signaling to tumor cell aggressiveness. We show that both canonical and noncanonical Hippo signaling modulates… CONTINUE READING
    A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation
    • 104
    • PDF
    Angiomotin Family Members: Oncogenes or Tumor Suppressors?
    • 16
    • Highly Influenced
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 43 REFERENCES
    Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
    • 469
    • PDF
    The emerging roles of YAP and TAZ in cancer
    • 560
    Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin*
    • 303
    • PDF
    Summaries of Affymetrix GeneChip probe level data.
    • 4,903
    • Highly Influential
    • PDF
    Angiomotin-like Proteins Associate with and Negatively Regulate YAP1*
    • 213
    • PDF
    A Rich1/Amot Complex Regulates the Cdc42 GTPase and Apical-Polarity Proteins in Epithelial Cells
    • 324
    The p130 Isoform of Angiomotin Is Required for Yap-Mediated Hepatic Epithelial Cell Proliferation and Tumorigenesis
    • 123