AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin1

  title={AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin1},
  author={C. Couderc and A. Boin and L. Fuhrmann and A. Vincent-Salomon and Vinay Mandati and Y. Kieffer and F. Mechta-Grigoriou and L. Del Maestro and P. Chavrier and D. Vallerand and I. Brito and T. Dubois and L. de Koning and D. Bouvard and D. Louvard and A. Gautreau and D. Lallemand},
  journal={Neoplasia (New York, N.Y.)},
  pages={10 - 24}
  • C. Couderc, A. Boin, +14 authors D. Lallemand
  • Published 2016
  • Biology, Medicine
  • Neoplasia (New York, N.Y.)
  • The Hippo signaling network is a key regulator of cell fate. In the recent years, it was shown that its implication in cancer goes well beyond the sole role of YAP transcriptional activity and its regulation by the canonical MST/LATS kinase cascade. Here we show that the motin family member AMOTL1 is an important effector of Hippo signaling in breast cancer. AMOTL1 connects Hippo signaling to tumor cell aggressiveness. We show that both canonical and noncanonical Hippo signaling modulates… CONTINUE READING
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