AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2.

@article{Pedersen2010AMNDE,
  title={AMN directs endocytosis of the intrinsic factor-vitamin B(12) receptor cubam by engaging ARH or Dab2.},
  author={Gitte Albinus Pedersen and Souvik Chakraborty and Amie L Steinhauser and Linton M. Traub and Mette Madsen},
  journal={Traffic},
  year={2010},
  volume={11 5},
  pages={706-20}
}
Cubam is a multi-ligand receptor involved in dietary uptake of intrinsic factor-vitamin B(12) in the small intestine and reabsorption of various low-molecular-weight proteins (such as albumin, transferrin, apolipoprotein A-I and vitamin D-binding protein) in the kidney. Cubam is composed of two proteins: cubilin and amnionless. Cubilin harbors ligand binding capabilities, while amnionless provides membrane anchorage and potential endocytic capacity via two FXNPXF signals within the cytosolic… CONTINUE READING