AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts.

@article{Sacchi1994AML1FT,
  title={AML1 fusion transcripts in t(3;21) positive leukemia: evidence of molecular heterogeneity and usage of splicing sites frequently involved in the generation of normal AML1 transcripts.},
  author={Nicoletta Sacchi and Paul E. Nisson and Paul C. Watkins and Fabrizia Faustinella and J A Wijsman and Anna Hagemeijer},
  journal={Genes, chromosomes & cancer},
  year={1994},
  volume={11 4},
  pages={226-36}
}
The t(3;21)(q26;q22) is associated with chronic myelogenous leukemia in blast crisis (CML-BC), leukemia evolving from (therapy-related) myelodysplasia, and with leukemia following other hematopoietic proliferative diseases. Molecular cytogenetic analysis and cloning of a few t(3;21) cases indicate that the breakpoints are quite heterogeneous even within a specific clinical phenotype. Interestingly some of the (3;21) breakpoints involve the AML1 gene previously found rearranged in the t(8;21… CONTINUE READING

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