AML1-ETO Inhibits Maturation of Multiple Lymphohematopoietic Lineages and Induces Myeloblast Transformation in Synergy with ICSBP Deficiency

@article{Schwieger2002AML1ETOIM,
  title={AML1-ETO Inhibits Maturation of Multiple Lymphohematopoietic Lineages and Induces Myeloblast Transformation in Synergy with ICSBP Deficiency},
  author={Maike Schwieger and J{\"u}rgen Loehler and Jutta Friel and Marina Scheller and Ivan Horak and Carol Stocking},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={196},
  pages={1227 - 1240}
}
The translocation (8;21), generating the AML1-ETO fusion protein, is one of the most frequent chromosomal abnormalities associated with acute myelogenous leukemia (AML). To elucidate its role in oncogenesis, bone marrow (BM) cells were infected with a retroviral vector carrying AML1-ETO and transplanted into mice. In contrast to previous transgenic mouse models, we show that AML1-ETO directly stimulates granulopoiesis, suppresses erythropoiesis, and impairs the maturation of myeloid, B, and T… CONTINUE READING