AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.

@article{Tang2009AML1RUNX1MI,
  title={AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations.},
  author={J L Tang and Hsin-An Hou and Chien-Yuan Chen and Chieh-Yu Liu and W.-C. Chou and Mei-Hsuan Tseng and Chi-Fei Huang and Fen-Yu Lee and M. C. Liu and Ming Yao and Sheng-Yi Huang and Bor-Sheng Ko and Szu-Chun Hsu and Shang-Ju Wu and Woei Tsay and Yao-Chang Chen and L Lin and H. -F. Tien},
  journal={Blood},
  year={2009},
  volume={114 26},
  pages={
          5352-61
        }
}
Somatic mutation of the AML1/RUNX1(RUNX1) gene is seen in acute myeloid leukemia (AML) M0 subtype and in AML transformed from myelodysplastic syndrome, but the impact of this gene mutation on survival in AML patients remains unclear. In this study, we sought to determine the clinical implications of RUNX1 mutations in 470 adult patients with de novo non-M3 AML. Sixty-three distinct RUNX1 mutations were identified in 62 persons (13.2%); 32 were in N-terminal and 31, C-terminal. The RUNX1… CONTINUE READING

Similar Papers

References

Publications referenced by this paper.
SHOWING 1-10 OF 45 REFERENCES

Acute myeloid leukemia: the challenge of capturing disease variety.

  • Hematology. American Society of Hematology. Education Program
  • 2008