AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.

@article{Steffen2011AML1ETOIS,
  title={AML1/ETO induces self-renewal in hematopoietic progenitor cells via the Groucho-related amino-terminal AES protein.},
  author={Bj{\"o}rn Steffen and Markus Knop and Ulla Bergholz and Olesya Vakhrusheva and Miriam Rode and Gabriele Koehler and M P Henrichs and Etmar Bulk and Sina Hehn and Martin Stehling and Martin Dugas and Nicole B{\"a}umer and Petra Tschanter and Christian Brandts and Steffen Koschmieder and Wolfgang E. Berdel and Hubert Serve and Carol Stocking and Carsten M{\"u}ller-Tidow},
  journal={Blood},
  year={2011},
  volume={117 16},
  pages={4328-37}
}
The most frequent translocation t(8;21) in acute myeloid leukemia (AML) generates the chimeric AML1/ETO protein, which blocks differentiation and induces self-renewal in hematopoietic progenitor cells. The underlying mechanisms mediating AML1/ETO-induced self-renewal are largely unknown. Using expression microarray analysis, we identified the Groucho-related amino-terminal enhancer of split (AES) as a consistently up-regulated AML1/ETO target. Elevated levels of AES mRNA and protein were… CONTINUE READING

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