AMH and AMH receptor defects in persistent Müllerian duct syndrome.

  title={AMH and AMH receptor defects in persistent M{\"u}llerian duct syndrome.},
  author={Nathalie Josso and Corinne Belville and N Di clemente and J F Picard},
  journal={Human reproduction update},
  volume={11 4},
Anti-Müllerian hormone (AMH) produced by fetal Sertoli cells is responsible for regression of Müllerian ducts, the anlage for uterus and Fallopian tubes, during male sex differentiation. A member of the transforming growth factor-beta superfamily, AMH signals through two transmembrane receptors, type II which is specific and type I receptors, shared with the bone morphogenetic protein family. Mutations of the AMH and AMH receptor type II (AMHR-II) genes lead to persistence of the uterus and… CONTINUE READING


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