AMG 151 (ARRY‐403), a novel glucokinase activator, decreases fasting and postprandial glycaemia in patients with type 2 diabetes

@article{Katz2016AMG1,
  title={AMG 151 (ARRY‐403), a novel glucokinase activator, decreases fasting and postprandial glycaemia in patients with type 2 diabetes},
  author={L. Katz and N. Manamley and W. J. Snyder and M. Dodds and N. Agafonova and J. Sierra-Johnson and M. Cruz and P. Kaur and S. Mudaliar and P. Raskin and R. Kewalramani and A. Pellacani},
  journal={Diabetes},
  year={2016},
  volume={18}
}
  • L. Katz, N. Manamley, +9 authors A. Pellacani
  • Published 2016
  • Medicine
  • Diabetes
  • Phase I studies have shown that AMG 151 activates glucokinase, a key enzyme in glucose homeostasis. The present randomized, placebo‐controlled phase IIa study evaluated the dose–effect relationship of the glucokinase activator AMG 151 relative to placebo on fasting plasma glucose (FPG) in 236 patients (33–35 patients per arm) with type 2 diabetes treated with metformin. Patients received oral AMG 151 at 50, 100 or 200 mg twice daily, AMG 151 at 100, 200 or 400 mg once daily or matching placebo… CONTINUE READING
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