AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins.

@article{Peng2000AMF1Gps2BP,
  title={AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins.},
  author={Ying Peng and David Breiding and Francis M Sverdrup and James Richard and Elliot J Androphy},
  journal={Journal of virology},
  year={2000},
  volume={74 13},
  pages={5872-9}
}
The cellular protein AMF-1 (Gps2) positively modulates gene expression by the papillomavirus E2 protein (D. E. Breiding et al., Mol. Cell. Biol. 17:7208-7219, 1997). We show here that AMF-1 also binds the transcriptional coactivator p300 in vitro and in vivo. E2 interacted weakly with p300. These observations led to a model in which AMF-1 recruits p300 into a complex with E2. Cotransfection of AMF-1 or p300 stimulated levels of E2-dependent transcription, while cotransfection of both AMF-1 and… CONTINUE READING
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