AMD3100/CXCR4 Inhibitor


The original bicyclam, JM1657 (JM standing for Johnson Matthey) was discovered as a contaminant in a commercial preparation of monocyclams when evaluated for their anti-HIV activity. The original compound, in which the cyclam rings were tethered by a C–C linkage could not be re-synthesized but launched the synthesis of new bicyclams in which the cyclam moieties were linked through an aliphatic bridge: one of these derivatives, i.e., JM2763, exhibited an anti-HIV activity similar to that of JM1657 (1). The compound was postulated to

DOI: 10.3389/fimmu.2015.00276

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@inproceedings{Clercq2015AMD3100CXCR4I, title={AMD3100/CXCR4 Inhibitor}, author={Erik de Clercq}, booktitle={Front. Immunol.}, year={2015} }