AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth

@article{Sari2020AMD1IR,
  title={AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth},
  author={Ita Novita Sari and Ying-Gui Yang and Yoseph Toni Wijaya and Nayoung Jun and Sanghyun Lee and Kwang Seock Kim and Jeevisha Bajaj and V. G. Oehler and Soo-hyun Kim and Soo Young Choi and Sahee Park and Dong-Wook Kim and Tannishtha Reya and Jaeseok Han and Hyog Young Kwon},
  journal={Oncogene},
  year={2020},
  volume={40},
  pages={603-617}
}
Polyamines are critical elements in mammals, but it remains unknown whether adenosyl methionine decarboxylase (AMD1), a rate-limiting enzyme in polyamine synthesis, is required for myeloid leukemia. Here, we found that leukemic stem cells (LSCs) were highly differentiated, and leukemia progression was severely impaired in the absence of AMD1 in vivo. AMD1 was highly upregulated as chronic myeloid leukemia (CML) progressed from the chronic phase to the blast crisis phase, and was associated with… 
Targeting Amino Acid Metabolic Vulnerabilities in Myeloid Malignancies
TLDR
Targeting amino acid metabolism provides a host of potential translational opportunities for exploitation to improve the outcomes for patients with myeloid malignancies.

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