AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells.

@article{Zhang2012AMD1IE,
  title={AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells.},
  author={Dawei Zhang and Tianyun Zhao and Haw Siang Ang and Peini Chong and Ryotaro Saiki and Kazuei Igarashi and Henry Yang and Leah A Vardy},
  journal={Genes & development},
  year={2012},
  volume={26 5},
  pages={461-73}
}
The gene expression networks governing embryonic stem cell (ESC) pluripotency are complex and finely regulated during differentiation toward specific lineages. We describe a new role for Amd1 (adenosyl methionine decarboxylase), a key enzyme in the polyamine synthesis pathway, in regulating both ESC self-renewal and differentiation to the neural lineage. Amd1 is highly expressed in ESCs and is translationally down-regulated by the neural precursor cell (NPC)-enriched microRNA miR-762 during NPC… CONTINUE READING

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