AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

  title={AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1},
  author={Flavie Strappazzon and Francesca Nazio and Marcella Corrado and Valentina Cianfanelli and A Romagnoli and Gian Maria Fimia and Silvia Campello and Roberta Nardacci and Mauro Piacentini and Michelangelo Campanella and Francesco Cecconi},
  journal={Cell Death and Differentiation},
Damaged mitochondria are eliminated by mitophagy, a selective form of autophagy whose dysfunction associates with neurodegenerative diseases. PINK1, PARKIN and p62/SQTMS1 have been shown to regulate mitophagy, leaving hitherto ill-defined the contribution by key players in ‘general’ autophagy. In basal conditions, a pool of AMBRA1 – an upstream autophagy regulator and a PARKIN interactor – is present at the mitochondria, where its pro-autophagic activity is inhibited by Bcl-2. Here we show that… CONTINUE READING
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