AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.

  title={AMBRA1 interplay with cullin E3 ubiquitin ligases regulates autophagy dynamics.},
  author={Manuela Antonioli and Federica Albiero and Francesca Nazio and Tiziana Vescovo and Ariel Basulto Perdomo and Marco Corazzari and Claudia Marsella and Pierluca Piselli and Christine Gretzmeier and Joern Dengjel and Francesco Cecconi and Mauro Piacentini and Gian Maria Fimia},
  journal={Developmental cell},
  volume={31 6},
Autophagy maintains cellular homeostasis by degrading harmful or unnecessary intracellular components. How the autophagy response is induced rapidly and transiently remains largely unknown. We report that the E3 ubiquitin ligases Cullin-5 and Cullin-4 regulate the onset and termination of autophagy, respectively, by dynamically interacting with AMBRA1, a regulator of autophagy. Under normal conditions, Cullin-4 binding to AMBRA1 limits its protein abundance. Autophagy stimuli promote AMBRA1… CONTINUE READING
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