AM630, a competitive cannabinoid receptor antagonist.

  title={AM630, a competitive cannabinoid receptor antagonist.},
  author={Roger G Pertwee and Graeme Griffin and Susanthi R. Fernando and Xiaowei Li and Alastair Hill and Alexandros Makriyannis},
  journal={Life sciences},
  volume={56 23-24},
AM630 (iodopravadoline), a novel aminoalkylindole, has been found to attenuate the ability of a number of cannabinoids to inhibit electrically-evoked twitches of the mouse isolated vas deferens. It did not block the inhibitory effects of morphine or clonidine on the twitch response. AM630 behaved as a competitive antagonist of CP 55,940, WIN 55,212-2, anandamide and (R)-(+)-arachidonyl-1'-hydroxy-2'-propylamide (AM356), producing rightward shifts in the log concentration response curves of… CONTINUE READING