AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN.

  title={AM3 modulates dendritic cell pathogen recognition capabilities by targeting DC-SIGN.},
  author={Diego Serrano-G{\'o}mez and Rocio T Martinez-Nunez and Elena Sierra-Filardi and Nuria Izquierdo and Mar{\'i}a Colmenares and Jesus Pla and Luis Enrique Urbina Rivas and Javier Martinez-Picado and Jes{\'u}s Jim{\'e}nez-Barbero and Jos{\'e} Luis Alonso-Lebrero and Salvador Gonz{\'a}lez and {\'A}ngel L Corb{\'i}},
  journal={Antimicrobial agents and chemotherapy},
  volume={51 7},
AM3 (Inmunoferon) is an orally effective immunomodulator that influences the regulatory and effector functions of the immune system whose molecular mechanisms of action are mostly unknown. We hypothesized that the polysaccharide moiety of AM3 (IF-S) might affect immune responses by modulating the lectin-dependent pathogen recognition abilities of human dendritic cells. IF-S inhibited binding of viral, fungal, and parasite pathogens by human monocyte-derived dendritic cells in a dose-dependent… CONTINUE READING
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