AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells
@article{Carpi2015AM251IA, title={AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells}, author={Sara Carpi and Stefano Fogli and Antonella Romanini and Mario Pellegrino and Barbara Adinolfi and Adriano Podest{\`a} and Barbara Costa and Eleonora Da Pozzo and Claudia Martini and Maria Cristina Breschi and Paola Nieri}, journal={Anti-Cancer Drugs}, year={2015}, volume={26}, pages={754–762} }
Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system. Characterization tools included a cell viability assay, nuclear morphology assessment, gene…
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