AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

@article{Carpi2015AM251IA,
  title={AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells},
  author={Sara Carpi and Stefano Fogli and Antonella Romanini and Mario Pellegrino and Barbara Adinolfi and Adriano Podest{\`a} and Barbara Costa and Eleonora Da Pozzo and Claudia Martini and Maria Cristina Breschi and Paola Nieri},
  journal={Anti-Cancer Drugs},
  year={2015},
  volume={26},
  pages={754–762}
}
Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system. Characterization tools included a cell viability assay, nuclear morphology assessment, gene… 
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18 Citations
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18 Citations

Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells.
  • S. Carpi, S. Fogli, P. Nieri
  • Biology
    Toxicology in vitro : an international journal published in association with BIBRA
  • 2017
Assessment of Cannabinoids Agonist and Antagonist in Invasion Potential of K562 Cancer Cells
TLDR
The findings clarifies that CB1 receptors are responsible for anti-invasive effects in the K562 cell line and shows that WIN 55212-2 considerably reduced cancer cell invasiveness, while AM251 exhibited a converse effect.
Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma.
TLDR
Evidence is provided that AIF may be useful as an antimetastatic agent in the treatment of melanoma by modulating COX-2 expression, at least in part, through targeting the miR-124/SphK1 axis.
Sinularin induces oxidative stress‐mediated G2/M arrest and apoptosis in oral cancer cells
TLDR
Taken together, sinularin induces oxidative stress‐mediated antiproliferation, G2/M arrest, and apoptosis against oral cancer cells and may be a potential marine drug for antioral cancer therapy.
Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression
TLDR
The data suggest that CB1 might be a potential target for RCC clinical therapy, as functionally associated to cellular proliferation, apoptosis, and invasion ability of RCC.
Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells
TLDR
The data provide the first evidence of the anti-melanoma activity of Euplotin C, suggesting it may be a promising new scaffold for the development of selective activators of RyR to be used for the treatment of melanoma and other cancer types.
Cannabinoids and their derivatives in struggle against melanoma
TLDR
It was pointed out that cannabinoids may be potentially useful in the melanoma therapy, but due to limited amount of data, great variety of cannabinoids available and lack of clinical trials, further studies are required to determine an exact role of cannabinoids in the treatment of melanoma.
Sulfonyl chromen-4-ones (CHW09) shows an additive effect to inhibit cell growth of X-ray irradiated oral cancer cells, involving apoptosis and ROS generation
TLDR
CHW09/X-ray treatment had additive growth inhibiting effects against X-ray irradiated oral cancer cells, partly attributing to apoptosis and ROS generation.
Impact of Cannabinoid Compounds on Skin Cancer
TLDR
A review of the anticarcinogenic mechanisms of cannabinoids at the different levels of skin cancer progression, such as inhibition of tumour growth, proliferation, invasion and angiogenesis, as well as inducing apoptosis and autophagy.
Cannabinoids as Anticancer Drugs.
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