AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

@article{Carpi2015AM251IA,
  title={AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells},
  author={Sara Carpi and Stefano Fogli and Antonella Romanini and Mario Pellegrino and Barbara Adinolfi and Adriano Podest{\`a} and Barbara Costa and Eleonora Da Pozzo and Claudia Martini and Maria Cristina Breschi and Paola Nieri},
  journal={Anti-Cancer Drugs},
  year={2015},
  volume={26},
  pages={754–762}
}
Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system. Characterization tools included a cell viability assay, nuclear morphology assessment, gene… Expand
Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells.
  • S. Carpi, S. Fogli, +6 authors P. Nieri
  • Biology, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2017
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