AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

  title={AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells},
  author={S. Carpi and S. Fogli and A. Romanini and M. Pellegrino and B. Adinolfi and A. Podest{\`a} and B. Costa and E. Da Pozzo and C. Martini and M. Breschi and P. Nieri},
  journal={Anti-Cancer Drugs},
Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system. Characterization tools included a cell viability assay, nuclear morphology assessment, gene… Expand
13 Citations
Tumor-promoting effects of cannabinoid receptor type 1 in human melanoma cells.
  • S. Carpi, S. Fogli, +6 authors P. Nieri
  • Biology, Medicine
  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2017
  • 14
Reduction of COX-2 through modulating miR-124/SPHK1 axis contributes to the antimetastatic effect of alpinumisoflavone in melanoma.
  • 19
  • PDF
Sinularin induces oxidative stress‐mediated G2/M arrest and apoptosis in oral cancer cells
  • 12
  • PDF
Overexpression of cannabinoid receptor 1 promotes renal cell carcinoma progression
  • 5
Anticancer Activity of Euplotin C, Isolated from the Marine Ciliate Euplotes crassus, Against Human Melanoma Cells
  • 15
  • PDF
Sulfonyl chromen-4-ones (CHW09) shows an additive effect to inhibit cell growth of X-ray irradiated oral cancer cells, involving apoptosis and ROS generation
  • 4
Cannabinoids as Anticancer Drugs.
  • 26
Cytotoxic Activity of Oleocanthal Isolated from Virgin Olive Oil on Human Melanoma Cells
  • 46


Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth Inhibition, G2-M arrest, and apoptosis.
  • 298
  • PDF
Anticancer activity of anandamide in human cutaneous melanoma cells.
  • 41
  • PDF
Revisiting CB1 Receptor as Drug Target in Human Melanoma
  • 14
Cannabinoid receptors as novel targets for the treatment of melanoma
  • 212
  • PDF