AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells

@article{Carpi2015AM251IA,
  title={AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells},
  author={S. Carpi and S. Fogli and A. Romanini and M. Pellegrino and B. Adinolfi and A. Podest{\`a} and B. Costa and E. Da Pozzo and C. Martini and M. Breschi and P. Nieri},
  journal={Anti-Cancer Drugs},
  year={2015},
  volume={26},
  pages={754–762}
}
Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed to characterize the in-vitro antimelanoma activity of AM251. The BRAF V600E mutant melanoma cell line, A375, was used as an in-vitro model system. Characterization tools included a cell viability assay, nuclear morphology assessment, gene… Expand
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