ALTERED TONIC CONDUCTANCES IN AXONS OF TRANSGENIC MOUSE EXPRESSING THE HUMAN NEUROFILAMENT HEAVY GENE: A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

@inproceedings{Kriz2000ALTEREDTC,
  title={ALTERED TONIC CONDUCTANCES IN AXONS OF TRANSGENIC MOUSE EXPRESSING THE HUMAN NEUROFILAMENT HEAVY GENE: A MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS},
  author={Jasna Kriz and Joaquim Meier and J P Julien and Al Padjen},
  year={2000}
}
Neurofilaments (NFs; made by copolymerization of three intermediate filament proteins NF-L, NF-M, and NF-H, for light, medium, and heavy) constitute the most abundant cytoskeletal structure in large myelinated axons. The presence of aberrant NF accumulation has been associated with neurodegenerative diseases (such as ALS). The possible causal role of NF in neurodegeneration has been supported by studies on recently available transgenic mice in which expression of human NF-H (hNF-H +/+) leads to… CONTINUE READING

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.

Chapter 6 Animal models of motor neuron death.

  • Handbook of clinical neurology
  • 2007
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED