ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM

@article{Agarwal1977ALTERATIONSIB,
  title={ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM},
  author={R. A. Agarwal and Yvon D. Lapierre and Ram B. Rastogi and Radhey L. Singhal},
  journal={British Journal of Pharmacology},
  year={1977},
  volume={60}
}
1 Daily administration of diazepam or bromazepam (10 mg/kg) for 22 days significantly increased the activity of mid‐brain tryptophan hydroxylase by 36% and 39%, respectively. The concentration of tryptophan was also enhanced in the mid‐brain region of rats subjected to benzodiazepine treatment. 2 Chronic therapy with either of the two anti‐anxiety agents enhanced the endogenous levels of 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid in cerebral cortex, hypothalamus, pons‐medulla, mid‐brain… 
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21 Citations

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TLDR
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There is no clear knowledge regarding an understanding of the reported effects of selegiline on the progression of Parkinson's disease, but some evidence suggests both an indirect (via induction of radical-scavenging enzymes) and a direct antioxidant function for seLegiline.
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