ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM

@article{Agarwal1977ALTERATIONSIB,
  title={ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM},
  author={R. A. Agarwal and Yvon D. Lapierre and Ram B. Rastogi and Radhey L. Singhal},
  journal={British Journal of Pharmacology},
  year={1977},
  volume={60}
}
1 Daily administration of diazepam or bromazepam (10 mg/kg) for 22 days significantly increased the activity of mid‐brain tryptophan hydroxylase by 36% and 39%, respectively. The concentration of tryptophan was also enhanced in the mid‐brain region of rats subjected to benzodiazepine treatment. 2 Chronic therapy with either of the two anti‐anxiety agents enhanced the endogenous levels of 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid in cerebral cortex, hypothalamus, pons‐medulla, mid‐brain… 
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21 Citations

21 Citations

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Studies on the interaction between cerebral 5‐hydroxytryptamine and γ‐aminobutyric acid in the mode of action of diazepam in the rat
TLDR
The hypothesis that doses of diazepam which result in total plasma concentrations comparable to those observed in man produce a reduction in 5‐HT turnover mediated via GABA neurones is discussed.
Some neurochemical correlates of "rebound" phenomenon observed during withdrawal after long-term exposure to 1, 4-benzodiazepines.
TLDR
It is demonstrated that benzodiazepines may display their tranquilizing action by producing antagonistic effects on catecholamine and 5-hydroxytryptamine neuronal systems.
Effects of chronic monoamine oxidase inhibitor treatment on biogenic amine metabolism in rat brain
TLDR
There was an associated adaptive increase in tryptophan hydroxylase but no change in tyrosine hydroxyase activity with chronic phenelzine treatment, and tranylcypromine was associated with a significant increase in aromatic amino acid decarboxylase activity after 14 and 21 days of treatment.
Clonazepam induces decreased serotoninergic activity in the mouse brain
TLDR
Clonazepam appears to increase brain tryptophan without altering 5HT synthesis, to decrease 5HT utilization and to inhibit the egress of 5HIAA from the brain.
Chlordiazepoxide loses its anxiolytic action with long-term treatment
TLDR
It appears that the reduction in 5HT turnover is linked to the anxiolytic effects of CDP; the latter were found after 5 days of drug treatment, but not after 15 or 25 days, using the social interaction test of anxiety.
Behavioural and adrenocortical responses to nicotine measured in rats with selective lesions of the 5‐hydroxytryptaminergic fibres innervating the hippocampus
TLDR
The data failed to provide any evidence that hippocampal 5‐HTergic systems may be implicated in the effects of nicotine on the spontaneous behaviour of the rat.
Brain 5-hydroxytryptamine metabolism: adaptive changes after long-term administration of psychotropic drugs.
TLDR
The data demonstrate that thyroid hormone plays an important role in the control of 5-HT metabolism especially in the developing brain, and the possibility is raised that anxiety, hypermobility and psychoses seen in hyperthyroid subjects are associated with increased serotonergic activity in the brain.
Diazepam modifies L-triiodothyronine-stimulated changes in behaviour and the metabolism of brain norepinephrine, dopamine and 5-hydroxytryptamine-a possible mechanism of action.
TLDR
Examination of the neuronal mechanisms underlying anxiolytic action of diazepam (DZP) in brain of neonatal hyperthyroid rats shows that this benzodiazepine reduces the T,stimulated changes in locomotor pkrformance as well as the catecholamine and 5-hydroxytryptamine (5-HT) synthesis and presumably turnover in certain discrete areas of the brain.
Neurotransmitter mechanisms during mental illness induced by alterations in thyroid function.
TLDR
Data demonstrate that depressed behavior and mental deficit seen in thyroid-ablated animals might be associated with decreased synthesis and turnover of brain NE, DA, and 5-HT as well as an increased accumulation of acetylcholine and ratio of ACh to DA.
Pharmacology of selegiline
TLDR
There is no clear knowledge regarding an understanding of the reported effects of selegiline on the progression of Parkinson's disease, but some evidence suggests both an indirect (via induction of radical-scavenging enzymes) and a direct antioxidant function for seLegiline.
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