ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM

@article{Agarwal1977ALTERATIONSIB,
  title={ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM},
  author={R. A. Agarwal and Yvon D. Lapierre and Ram B. Rastogi and Radhey L. Singhal},
  journal={British Journal of Pharmacology},
  year={1977},
  volume={60}
}
1 Daily administration of diazepam or bromazepam (10 mg/kg) for 22 days significantly increased the activity of mid‐brain tryptophan hydroxylase by 36% and 39%, respectively. The concentration of tryptophan was also enhanced in the mid‐brain region of rats subjected to benzodiazepine treatment. 2 Chronic therapy with either of the two anti‐anxiety agents enhanced the endogenous levels of 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid in cerebral cortex, hypothalamus, pons‐medulla, mid‐brain… 
21 Citations
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References

SHOWING 1-10 OF 46 REFERENCES
EVIDENCE FOR THE ROLE OF BRAIN BIOGENIC AMINES IN DEPRESSED MOTOR ACTIVITY SEEN IN CHEMICALLY THYROIDECTOMIZED RATS 1
TLDR
The data support the view that thyroid hormone in neonatal life displays an important regulatory effect on the metabolism of norepinephrine, dopamine and 5‐hydroxytryptamine in maturing brain.
Thyroid hormone control of 5-hydroxytryptamine metabolism in developing rat brain.
TLDR
It is indicated that thyroid hormone influences 5-hydroxytryptamine levels of developing brain and that a critical period exists in early postnatal life during which this hormone must be present in order to permit the normal ontogeny of the metabolism of this putative neurotransmitter.
Effect of psychotropic drugs on tryptophan concentration in the rat brain.
The administration of d -amphetamine. reserpine, dibutyryl cyclic adenosine monophosphate and lithium or the exposure to hot environmental temperature, conditions known to increase brain serotonin
Changes in norepinephrine turnover in rat brain during chronic administration of imipramine and protriptyline: a possible explanation for the delay in onset of clinical antidepressant effects.
TLDR
The authors compare the effects of acute and chronic administration of the tricyclic antidepressants imipramine and protriptyline on the turnover and matabolism of norepinephrine in rat brain to help explain why clinical antidepressant effects are generally observed only after chronic treatment with these drugs.
Effects of benzodiazepines on central serotonergic mechanisms.
TLDR
Results parallel findings in the conflict test which indicate that the depressant action of oxazepam rapidly undergoes tolerance, whereas the anxiety-reducing action is maintained over repeated doses, suggesting that the drugs actually act indirectly to reduce serotonin activity.
Benzodiazepines: Anxiety-Reducing Activity by Reduction of Serotonin Turnover in the Brain
TLDR
The anxiety-reducing activity, and the decrease in serotonin turnover induced by benzodiazepines, were maintained over repeated doses, whereas depressant activity,and the decrease induced in norepinephrine turnover, both rapidly underwent tolerance.
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