ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM

@article{Agarwal1977ALTERATIONSIB,
  title={ALTERATIONS IN BRAIN 5‐HYDROXY‐TRYPTAMINE METABOLISM DURING THE ‘WITHDRAWAL’ PHASE AFTER CHRONIC TREATMENT WITH DIAZEPAM AND BROMAZEPAM},
  author={R. A. Agarwal and Yvon D. Lapierre and Ram B. Rastogi and Radhey L. Singhal},
  journal={British Journal of Pharmacology},
  year={1977},
  volume={60}
}
1 Daily administration of diazepam or bromazepam (10 mg/kg) for 22 days significantly increased the activity of mid‐brain tryptophan hydroxylase by 36% and 39%, respectively. The concentration of tryptophan was also enhanced in the mid‐brain region of rats subjected to benzodiazepine treatment. 2 Chronic therapy with either of the two anti‐anxiety agents enhanced the endogenous levels of 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid in cerebral cortex, hypothalamus, pons‐medulla, mid‐brain… 
21 Citations
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