ALSFRS‐R

@article{Gordon2004ALSFRSR,
  title={ALSFRS‐R},
  author={Paul H. Gordon and Robert G. Miller and D. Moore},
  journal={Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders},
  year={2004},
  volume={5},
  pages={90 - 93}
}
The ALSFRS‐R is an attractive primary outcome measure in clinical trials of ALS because it is validated, easy to administer, minimizes dropout, reduces cost, and correlates with survival. Unlike the other standard outcome measures currently employed, the ALSFRS‐R is also a measure of global function. 

Using the ALSFRS-R in multicentre clinical trials for amyotrophic lateral sclerosis: potential limitations in current standard operating procedures

Sudden 5-point or more increases in ALSFRS-R total scores between two consecutive visits are relatively common, but these sudden increases were not found to occur with equal frequency in trial centers, which underscores the need for amending existing standard operating procedures toward a universal version.

Primary lateral sclerosis (PLS) functional rating scale: PLS‐specific clinimetric scale

Our research aim was to develop a novel clinimetric scale sensitive enough to detect disease progression in primary lateral sclerosis (PLS).

Assessing upper limb function with ALSFRS-R in amyotrophic lateral sclerosis patients

ALSFRS-R is an important tool to assess functional UL involvement in ALS, however, it can mislead clinicians when evaluating right-handed patients with initial LUL onset form.

Validation of the Italian version of the Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS) administered to patients and their caregivers

The Italian version of the ROADS scale is a valid and reliable tool to monitor disease burden, showing a high level of agreement between the responses given by patients and caregivers.

Validation of the revised Amyotrophic Lateral Sclerosis Functional Rating Scale in Poland and its reliability in conditions of the medical experiment

Validation of the Polish version of the ALSFRS-R supports the reliability and internal consistency of scale and proved also to be a proper tool for monitoring the course of the experimental medical therapy for patients with ALS.

Clinical Measures of Bulbar Dysfunction in ALS

A comprehensive appraisal of the most commonly utilized clinical tools for assessing and monitoring bulbar dysfunction in ALS based on the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) evaluation framework is provided.

Regional spreading of symptoms at diagnosis as a prognostic marker in amyotrophic lateral sclerosis: a population-based study

The evaluation of number of body regions involved (NBRI) at diagnosis, with the inclusion of initial respiratory/thoracic involvement and cognition, can be useful in many research fields, improving the stratification of patients.

Association Between Dietary Intake and Function in Amyotrophic Lateral Sclerosis.

Regression analysis of nutrients found that higher intakes of antioxidants and carotenes from vegetables were associated with higher ALSFRS-R scores or percentage FVC, and the usefulness of the weighted quantile sum regression method in the evaluation of diet was demonstrated.

Evidence of multidimensionality in the ALSFRS-R Scale: a critical appraisal on its measurement properties using Rasch analysis

The ALSFRS-R fails to satisfy rigorous measurement standards and should be revised, at least in part, revised.

Effects of prolonged interruption of rehabilitation routines in amyotrophic lateral sclerosis patients.

Prolonged interruption of rehabilitation during the lockdown may have accelerated the functional decline in ALS patients’ motor skills with as measured after 2 months by the ALSFRS-R in the limb and bulbar subscores, but not respiratory subscore.

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