ALS with respiratory onset: Clinical features and effects of non-invasive ventilation on the prognosis

@article{Gautier2010ALSWR,
  title={ALS with respiratory onset: Clinical features and effects of non-invasive ventilation on the prognosis},
  author={Guillaume Gautier and Annie Verschueren and Armelle Monnier and Shahram Attarian and Emmanuelle Salort-Campana and Jean Pouget},
  journal={Amyotrophic Lateral Sclerosis},
  year={2010},
  volume={11},
  pages={379 - 382}
}
Abstract Respiratory muscle involvement is one of the main prognostic factors in amyotrophic lateral sclerosis (ALS). Acute respiratory failure is sometimes the first manifestation of the disease, although onset can be more insidious. In the present retrospective study, it was proposed to review the clinical features and to assess the effects of non-invasive ventilation (NIV) on the prognosis of patients with respiratory onset, which was taken to be present when the first symptoms of muscular… 

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  • H. NzwaloM. de Carvalho
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2012
The patient presented with progressive RI, signs of upper motor neuron dysfunction in one limb and widespread neurogenic signs on EMG which made the diagnosis of ALS, a severe restrictive pulmonary disease with severe involvement of the respiratory muscles, particularly the diaphragm.
...

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