ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons

@inproceedings{Lenzi2015ALSMF,
  title={ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons},
  author={Jessica Lenzi and Riccardo De Santis and Valeria de Turris and Mariangela Morlando and Pietro Laneve and Andrea Calvo and Virginia Caliendo and Adriano Chi{\`o} and Alessandro Rosa and Irene Bozzoni},
  booktitle={Disease models & mechanisms},
  year={2015}
}
Patient-derived induced pluripotent stem cells (iPSCs) provide an opportunity to study human diseases mainly in those cases for which no suitable model systems are available. Here, we have taken advantage of in vitro iPSCs derived from patients affected by amyotrophic lateral sclerosis (ALS) and carrying mutations in the RNA-binding protein FUS to study the… CONTINUE READING