ALS diagnostic criteria of El Escorial Revisited: do they meet the needs of clinicians as well as researchers?

  title={ALS diagnostic criteria of El Escorial Revisited: do they meet the needs of clinicians as well as researchers?},
  author={Jerry M. Belsh},
  journal={Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders},
  pages={S57 - S60}
  • J. Belsh
  • Published 1 March 2000
  • Medicine
  • Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
The El Escorial criteria for diagnosis of amyotrophic lateral sclerosis (ALS) have been in use for almost a decade. A revised set of criteria, meant to supersede the original set, was developed at a 1998 World Federation of Neurology (WFN) ALS meeting at Airlie House in Warrenton, Virginia, USA. This revised document, nicknamed El Escorial Revisited, has been published on the WFN-ALS website. El Escorial has proven useful in standardizing diagnostic criteria for entry into research trials and… 

The revised El Escorial criteria “clinically probable laboratory supported ALS”—once a promising now a superfluous category?

In the PRO-ACT dataset, progression in ALS patients included at baseline into the “clinically probable laboratory supported” category was significantly slower compared to the other EEC categories and exhibited a significantly longer diagnostic delay, suggesting that the bias toward slow progressors in this category is an inherent problem of the category.

Gold Coast diagnostic criteria increase sensitivity in amyotrophic lateral sclerosis

Considerations on the concept, definition, and diagnosis of amyotrophic lateral sclerosis

The identification of effective and objective biomarkers may be a feasible method for the early and accurate diagnosis of ALS and future research should focus on the identification of reliable biomarkers—especially neuroimaging biomarker—through autopsy.

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The efficacy and safety of edaravone in amyotrophic lateral sclerosis patients with a Japan ALS severity classification of Grade 3 were explored and there was no intergroup difference in the changes in the ALSFRS-R score.

FTD and ALS: a tale of two diseases.

A better understanding of the clinical, pathological and genetic features characterizing FTD and ALS will shed light into overlaps among these two disorders and the underpinning mechanisms that contribute to the onset and development.

A clinical epidemiological study of 251 cases of amyotrophic lateral sclerosis in the south of Brazil.

Domestic work and heavy occupations appear to be related to precocious perception of the symptoms by interference with daily functions in patients with clinical forms of amyotrophic lateral sclerosis in Paraná, Brazil.

Chapter 16 Primary lateral sclerosis.

  • A. Eisen
  • Psychology, Medicine
    Handbook of clinical neurology
  • 2007

Amyotrophic lateral sclerosis: Analysis of ALS cases in a predominantly admixed population of Ecuador

Investigation in the predominantly admixed population of Ecuador found that ALS incidence in the Ecuadorian hospital population is in accord with rates reported in recent studies for other admixed populations, and lower than that in the United States and Europe.

Amiyotrofik Lateral Skleroz

This study confirms the specificity of Bunina bodies in sporadic ALS and evaluated the motor cortex, hypoglossal nucleus and spinal cord sections from autopsies of these ALS patients and 7 controls, focusing on the Specificity of Bunine bodies and ub-ir inclusions.



Toward earlier diagnosis of amyotrophic lateral sclerosis

The World Federation of Neurology diagnostic criteria for ALS was modified and used for enrollment of ALS patients in a clinical trial and the diagnosis of ALS was believed to be accurate in those patients entered in the trial.

ALS Diagnostic criteria, El Escorial, and Philip II of Spain: A historical perspective

  • J. Belsh
  • History
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
  • 1999
El Escorial, a magnificent palace-monastery in central Spain, was the setting in 1990 for a meeting of ALS experts who developed a consensus document called the El Escorial ALS Diagnostic Criteria.

Amyotrophic lateral sclerosis : diagnosis and management for the clinician

Part 1: DIAGNOSIS 1. Epidemiology and Historical Perspective of ALS 2. Etiology and Pathogenesis of ALS: Biochemical, Genetic, and Other Theories 3. Definition of Terms, Classification, and

Consensus guidelines for the design and implementation of clinical trials in ALS

Misdiagnosis in patients with amyotrophic lateral sclerosis.

Most likely causes of misdiagnosis were physicians' failure to consider the diagnosis and lack of familiarity with the common clinical presentations of amyotrophic lateral sclerosis.

Misdiagnosis in ALS: therapeutic and psychological implications

  • Presented at 5 International Symposium on ALS/MND, Noordwijk, Holland,
  • 1994

Differential diagnosis of ALS: Part I. Non-motor neuron diseases and adult-onset spinal muscular atrophies

  • Armonk, NY: Futura,
  • 1996