ALS and FTLD: two faces of TDP-43 proteinopathy.

  title={ALS and FTLD: two faces of TDP-43 proteinopathy.},
  author={Rajka M Liscic and Lea Tenenholz Grinberg and Janez Zidar and Michael A. Gitcho and Nigel J. Cairns},
  journal={European journal of neurology},
  volume={15 8},
Major discoveries have been made in the recent past in the genetics, biochemistry and neuropathology of frontotemporal lobar degeneration (FTLD). TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, has been identified as the major pathological protein of FTLD with ubiquitin-immunoreactive (ub-ir) inclusions (FTLD-U) with or without amyotrophic lateral sclerosis (ALS) and sporadic ALS. Recently, mutations in the TARDBP gene in familial and sporadic ALS have been reported which… CONTINUE READING
55 Citations
85 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 55 extracted citations


Publications referenced by this paper.
Showing 1-10 of 85 references

Similar Papers

Loading similar papers…