ALS and FTLD: two faces of TDP-43 proteinopathy.

@article{Liscic2008ALSAF,
  title={ALS and FTLD: two faces of TDP-43 proteinopathy.},
  author={Rajka M Liscic and Lea Tenenholz Grinberg and Janez Zidar and Michael A. Gitcho and Nigel J. Cairns},
  journal={European journal of neurology},
  year={2008},
  volume={15 8},
  pages={772-80}
}
Major discoveries have been made in the recent past in the genetics, biochemistry and neuropathology of frontotemporal lobar degeneration (FTLD). TAR DNA-binding protein 43 (TDP-43), encoded by the TARDBP gene, has been identified as the major pathological protein of FTLD with ubiquitin-immunoreactive (ub-ir) inclusions (FTLD-U) with or without amyotrophic lateral sclerosis (ALS) and sporadic ALS. Recently, mutations in the TARDBP gene in familial and sporadic ALS have been reported which… CONTINUE READING
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