ALS and FTD: an epigenetic perspective

  title={ALS and FTD: an epigenetic perspective},
  author={Veronique Belzil and Rebecca B. Katzman and Leonard Petrucelli},
  journal={Acta Neuropathologica},
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two fatal neurodegenerative diseases seen in comorbidity in up to 50 % of cases. Despite tremendous efforts over the last two decades, no biomarkers or effective therapeutics have been identified to prevent, decelerate, or stop neuronal death in patients. While the identification of multiple mutations in more than two dozen genes elucidated the involvement of several mechanisms in the pathogenesis of both diseases… CONTINUE READING