ALS IgGs suppress [Ca2+]i rise through P/Q-type calcium channels in central neurones in culture.

@article{Andjus1996ALSIS,
  title={ALS IgGs suppress [Ca2+]i rise through P/Q-type calcium channels in central neurones in culture.},
  author={Pavle R. Andjus and Leonard S Khiroug and Andrea Nistri and Enrico Cherubini},
  journal={Neuroreport},
  year={1996},
  volume={7 12},
  pages={1914-6}
}
Confocal laser scanning microscopy (with the fluorescent calcium dye fluo-3) was used to test the effect of IgG obtained from patients with amyotrophic lateral sclerosis (ALS) on the KCl-induced [Ca2+] rise in rat hippocampal neurones in culture. In the presence of tetrodotoxin and ionotropic glutamate receptor antagonists, ALS IgGs depressed (by 30-40%) Ca2+ transients evoked by influx of Ca2+ through voltage-activated channels; such an effect did not occur with IgG obtained from healthy… CONTINUE READING

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