ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.

@article{Elias2016ALOX5APOI,
  title={ALOX5AP Overexpression in Adipose Tissue Leads to LXA4 Production and Protection Against Diet-Induced Obesity and Insulin Resistance.},
  author={Ivet Elias and Tura Ferr{\'e} and Laia Vil{\`a} and Sergio Fructuoso Mu{\~n}oz and Alba Casellas and Miquel Garc{\'i}a and M. Pineda Molas and Judith Agudo and Carles Roca and Jes{\'u}s Ruberte and Fatima Bosch and Sylvie Franckhauser},
  journal={Diabetes},
  year={2016},
  volume={65 8},
  pages={2139-50}
}
Eicosanoids, such as leukotriene B4 (LTB4) and lipoxin A4 (LXA4), may play a key role during obesity. While LTB4 is involved in adipose tissue inflammation and insulin resistance, LXA4 may exert anti-inflammatory effects and alleviate hepatic steatosis. Both lipid mediators derive from the same pathway, in which arachidonate 5-lipoxygenase (ALOX5) and its… CONTINUE READING