ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.

@article{Tellera2008ALOX5PG,
  title={ALOX5 promoter genotype and response to montelukast in moderate persistent asthma.},
  author={Juan Jos{\'e} Teller{\'i}a and Alfredo A Blanco-Quir{\'o}s and David Varillas and Alicia Armentia and Isabel Fern{\'a}ndez-Carvajal and M Jesus Alonso and Ignacio D{\'i}ez},
  journal={Respiratory medicine},
  year={2008},
  volume={102 6},
  pages={857-61}
}
BACKGROUND It was hypothesized that asthmatic patients with mutant alleles in the leukotriene pathway should not respond to leukotriene receptor antagonists and the concept of a tailored treatment is increasingly supported. METHODS Sixty-one patients (mean age 24.9 years, range 14-52) with moderate persistent asthma were clinical and immunological assess prior and after a 6-month treatment with montelukast. Tandem repeat polymorphisms were genotyped in the promoter (-147 to -176) of 5… CONTINUE READING