ALLOPURINOL AND OXIPURINOL: ALTERATION OF PURINE AND PYRIMIDINE METABOLISM IN CELL CULTURE

@article{Keley1971ALLOPURINOLAO,
  title={ALLOPURINOL AND OXIPURINOL: ALTERATION OF PURINE AND PYRIMIDINE METABOLISM IN CELL CULTURE},
  author={William N. Ke'ley and I. Fox and T. Beardmore and J. Meade},
  journal={Annals of the New York Academy of Sciences},
  year={1971},
  volume={179}
}
Allopurinol, an analogue of hypoxanthine, is a potent inhibitor of xanthine oxidase, the enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid'-' (FIGURE 1). As a result of this property, allopurinol reduces the synthesis of uric acid and is widely used in the treatment of gout and other disorders characterized by hyperuricemia.610 Recent studies have suggested that the effects of allopurinol in vim extend beyond inhibition of xanthine oxidase. Several… Expand
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The failure of allopurinol to enhance 6-mercaptopurine toxicity in rabbits.
Hyperuricemia and Gout
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