ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.

@article{Ray2010ALK5PO,
  title={ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.},
  author={B. N. Bhramar Ray and Nam Yong Lee and Tam How and Gerard C. Blobe},
  journal={Carcinogenesis},
  year={2010},
  volume={31 3},
  pages={435-41}
}
Endoglin, an endothelial cell-specific transforming growth factor-beta (TGF-beta) superfamily coreceptor, has an essential role in angiogenesis. Endoglin-null mice have an embryonic lethal phenotype due to defects in angiogenesis and mutations in endoglin result in the vascular disease hereditary hemorrhagic telangiectasia type I. Increased endoglin expression in the proliferating endothelium of tumors has been correlated with metastasis, tumor grade and decreased survival. Although endoglin is… CONTINUE READING

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Hereditary hemorrhagic telangiectasiaPathogenesis of disease involves geneENG gene
Endoglin - null mice have an embryonic lethal phenotype due to defects in angiogenesis and mutations in endoglin result in the vascular disease hereditary hemorrhagic telangiectasia type I. Increased endoglin expression in the proliferating endothelium of tumors has been correlated with metastasis , tumor grade and decreased survival .
Endoglin - null mice have an embryonic lethal phenotype due to defects in angiogenesis and mutations in endoglin result in the vascular disease hereditary hemorrhagic telangiectasia type I. Increased endoglin expression in the proliferating endothelium of tumors has been correlated with metastasis , tumor grade and decreased survival .
Endoglin , an endothelial cell - specific transforming growth factor - beta ( TGF - beta ) superfamily coreceptor , has an essential role in angiogenesis .
Endoglin , an endothelial cell - specific transforming growth factor - beta ( TGF - beta ) superfamily coreceptor , has an essential role in angiogenesis .
Transforming Growth FactorsIs biochemical function of gene productTransforming Growth Factor beta
Endoglin , an endothelial cell - specific transforming growth factor - beta ( TGF - beta ) superfamily coreceptor , has an essential role in angiogenesis .
Endoglin - null mice have an embryonic lethal phenotype due to defects in angiogenesis and mutations in endoglin result in the vascular disease hereditary hemorrhagic telangiectasia type I. Increased endoglin expression in the proliferating endothelium of tumors has been correlated with metastasis , tumor grade and decreased survival .
Endoglin - null mice have an embryonic lethal phenotype due to defects in angiogenesis and mutations in endoglin result in the vascular disease hereditary hemorrhagic telangiectasia type I. Increased endoglin expression in the proliferating endothelium of tumors has been correlated with metastasis , tumor grade and decreased survival .
Endoglin - null mice have an embryonic lethal phenotype due to defects in angiogenesis and mutations in endoglin result in the vascular disease hereditary hemorrhagic telangiectasia type I. Increased endoglin expression in the proliferating endothelium of tumors has been correlated with metastasis , tumor grade and decreased survival .
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