ALK rearrangement in sickle cell trait‐associated renal medullary carcinoma

@article{MarioEnriquez2011ALKRI,
  title={ALK rearrangement in sickle cell trait‐associated renal medullary carcinoma},
  author={Adrian Mari{\~n}o-Enriquez and Wenbin Ou and Christopher B Weldon and Jonathan A. Fletcher and Antonio R. Perez-Atayde},
  journal={Genes},
  year={2011},
  volume={50}
}
Renal Medullary Carcinoma (RMC) is an aggressive malignancy that affects young black individuals with sickle cell trait. No effective treatment is available, resulting in an ominous clinical course, with overall survival averaging less than four months. We report rearrangement of the ALK receptor tyrosine kinase in a pediatric case of RMC harboring a t(2;10)(p23;q22) translocation. Mass spectrometry‐based proteomic evaluation identified a novel ALK oncoprotein in which the cytoskeletal protein… 
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TLDR
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