ALK gene copy number gain and its clinical significance in hepatocellular carcinoma.

@article{Jia2014ALKGC,
  title={ALK gene copy number gain and its clinical significance in hepatocellular carcinoma.},
  author={Shou-Wei Jia and Sha Fu and Fang Wang and Qiong Shao and Hong-Bing Huang and Jian Shao},
  journal={World journal of gastroenterology},
  year={2014},
  volume={20 1},
  pages={183-92}
}
AIM To examine the status and clinical significance of anaplastic lymphoma kinase (ALK) gene alterations in hepatocellular carcinoma (HCC) patients. METHODS A total of 213 cases of HCC were examined by fluorescent in situ hybridization using dual color break-apart ALK probes for the detection of chromosomal translocation and gene copy number gain. HCC tissue microarrays were constructed, and the correlation between the ALK status and clinicopathological variables was assessed by χ(2) test or… CONTINUE READING
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