ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients

@article{Sukov2012ALKAI,
  title={ALK alterations in adult renal cell carcinoma: frequency, clinicopathologic features and outcome in a large series of consecutively treated patients},
  author={William R. Sukov and Jennelle C. Hodge and Christine Marie Lohse and Monica K Akre and Bradley C. Leibovich and Robert Thompson and John C. Cheville},
  journal={Modern Pathology},
  year={2012},
  volume={25},
  pages={1516-1525}
}
Chromosomal rearrangements involving the anaplastic lymphoma kinase gene (ALK) at 2p23 result in fusion with various partner genes leading to aberrant production of oncogenic protein products in multiple tumor types. Recently, the ALK protein inhibitor crizotinib was shown to be an effective therapy in patients with ALK-rearranged non-small cell lung cancer. The goal of this study was to determine the frequency of ALK alterations in adult renal cell carcinoma (RCC) and define associated… CONTINUE READING

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