ALK Inhibitors, a Pharmaceutical Perspective

  title={ALK Inhibitors, a Pharmaceutical Perspective},
  author={Elena Ardini and Arturo Galvani},
  booktitle={Front. Oncol.},
In 2007, the ALK tyrosine kinase was described as a potential therapeutic target for a subset of non-small-cell lung cancer patients. Clinical proof of concept, culminating in the recent approval by the Food and Drug Administration of the Pfizer drug crizotinib followed in record time. The drug was approved together with a companion diagnostic for detection of patients eligible for therapy. This remarkable example of the coming of age of personalized medicine in cancer therapy is hopefully only… CONTINUE READING

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