ALK: a tyrosine kinase target for cancer therapy

  title={ALK: a tyrosine kinase target for cancer therapy},
  author={Vijaykumar R. Holla and Yasir Y. Elamin and Ann M. Bailey and Amber M. Johnson and Beate Litzenburger and Yekaterina Khotskaya and Nora S. Sanchez and Jia Zeng and Md Abu Shufean and Kenna R. Mills Shaw and John Mendelsohn and Gordon B. Mills and Funda Meric-Bernstam and George Rajan Simon},
  booktitle={Cold Spring Harbor molecular case studies},
The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the development of the brain and can be oncogenically altered in several malignancies, including non-small-cell lung cancer (NSCLC) and anaplastic large cell lymphomas (ALCL). Most prevalent ALK alterations are chromosomal rearrangements resulting in fusion genes, as seen in ALCL and NSCLC. In other tumors, ALK copy-number gains and activating ALK mutations have been described. Dramatic and often prolonged… CONTINUE READING
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