ALIX Is Recruited Temporarily into HIV-1 Budding Sites at the End of Gag Assembly

@inproceedings{Ku2014ALIXIR,
  title={ALIX Is Recruited Temporarily into HIV-1 Budding Sites at the End of Gag Assembly},
  author={Pei-I Ku and Mourad Bendjennat and Jeff Ballew and Michael B. Landesman and Saveez Saffarian},
  booktitle={PloS one},
  year={2014}
}
Polymerization of Gag on the inner leaflet of the plasma membrane drives the assembly of Human Immunodeficiency Virus 1 (HIV-1). Gag recruits components of the endosomal sorting complexes required for transport (ESCRT) to facilitate membrane fission and virion release. ESCRT assembly is initiated by recruitment of ALIX and TSG101/ESCRT-I, which bind directly to the viral Gag protein and then recruit the downstream ESCRT-III and VPS4 factors to complete the budding process. In contrast to… CONTINUE READING

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