ALDH1B1 links alcohol consumption and diabetes.

  title={ALDH1B1 links alcohol consumption and diabetes.},
  author={Surendra Singh and Yin Chen and Akiko Matsumoto and David J Orlicky and Hongbin Dong and David C. Thompson and Vasilis Vasiliou},
  journal={Biochemical and biophysical research communications},
  volume={463 4},
Aldehyde dehydrogenase 1B1 (ALDH1B1) is a mitochondrial enzyme sharing 65% and 72% sequence identity with ALDH1A1 and ALDH2 proteins, respectively. Compared to the latter two ALDH isozymes, little is known about the physiological functions of ALDH1B1. Studies in humans indicate that ALDH1B1 may be associated with alcohol sensitivity and stem cells. Our recent in vitro studies using human ALDH1B1 showed that it metabolizes acetaldehyde and retinaldehyde. To investigate the in vivo role of… CONTINUE READING
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