ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling

@article{Meng2014ALDH1A1MO,
  title={ALDH1A1 Maintains Ovarian Cancer Stem Cell-Like Properties by Altered Regulation of Cell Cycle Checkpoint and DNA Repair Network Signaling},
  author={Erhong Meng and Aparna Mitra and Kaushlendra Mani Tripathi and Michael Finan and Jennifer M. Scalici and Steven McClellan and Luciana Madeira da Silva and Eddie Reed and Lalita A Shevde and Komaraiah Palle and Rodney P Rocconi},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Objective Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem cell-like properties and their role in platinum resistance. Methods Isogenic ovarian cancer cell lines for platinum sensitivity (A2780) and platinum resistant (A2780/CP70) as well as ascites from ovarian cancer patients were analyzed for ALDH+ by flow cytometry to determine its association to platinum resistance, recurrence and survival… Expand
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