ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome.

@article{Wang2012ALDH1brightEO,
  title={ALDH1-bright epithelial ovarian cancer cells are associated with CD44 expression, drug resistance, and poor clinical outcome.},
  author={Yu-Chi Wang and Yi-Te Yo and Hsin-Yi Lee and Yu-ping Liao and T. Y. Chao and Po-Hsuan Su and Hung Cheng Lai},
  journal={The American journal of pathology},
  year={2012},
  volume={180 3},
  pages={1159-69}
}
The role of aldehyde dehydrogenase 1 (ALDH1) as an ovarian cancer stem cell marker and its clinical significance have rarely been explored. We used an Aldefluor assay to isolate ALDH1-bright (ALDH1(br)) cells from epithelial ovarian cancer cell lines and characterized the properties of the stem cells. ALDH1(br) cells were enriched in ES-2 (1.3%), TOV-21G (1.0%), and CP70 (1.2%) cells. Both ALDH1(br) and ALDH1(low) cells repopulated stem cell heterogeneity, formed spheroids, and grew into tumors… CONTINUE READING

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