ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.

@article{Oliveri2012ALAS1GE,
  title={ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.},
  author={Leda Mar{\'i}a Oliveri and Carlos A. Davio and Alcira Batlle and Esther Noem{\'i} Gerez},
  journal={The Biochemical journal},
  year={2012},
  volume={442 2},
  pages={303-10}
}
Porphyrias are diseases caused by partial deficiencies of haem biosynthesis enzymes. Acute porphyrias are characterized by a neuropsychiatric syndrome with intermittent induction of hepatic ALAS1 (δ-aminolaevulinate synthase 1), the first and rate-limiting enzyme of the haem pathway. Acute porphyria attacks are usually treated by the administration of glucose; its effect is apparently related to its ability to inhibit ALAS1 by modulating insulin plasma levels. It has been shown that insulin… CONTINUE READING
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