AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance

  title={AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance},
  author={Romina Burla and Mariateresa Carcuro and Grazia Daniela Raffa and Alessandra Galati and Domenico Raimondo and Angela Maria Rizzo and Mattia La Torre and Emanuela Micheli and Laura Ciapponi and Giovanni Cenci and Enrico Cundari and Antonio Musio and Annamaria Biroccio and Stefano Cacchione and Maurizio Gatti and Isabella Saggio},
  journal={PLoS Genetics},
Telomeres are nucleoprotein complexes that protect the ends of linear chromosomes from incomplete replication, degradation and detection as DNA breaks. Mammalian telomeres are protected by shelterin, a multiprotein complex that binds the TTAGGG telomeric repeats and recruits a series of additional factors that are essential for telomere function. Although many shelterin-associated proteins have been so far identified, the inventory of shelterin-interacting factors required for telomere… 

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